After studying at City College of San Francisco, Hosea obtained a B.S. in Chemistry from University of California Berkeley and a Ph.D. from the California Institute of Technology in 2012 under the mentorship of Brian Stoltz. After postdoctoral training at University of California Berkeley with Dean Toste, Hosea joined the UCLA faculty in 2015 as an assistant professor. In 2021 he moved his group to Caltech where they currently focus on developing enabling technologies for the biomedical sciences. More specifically they utilize cutting-edge electron microscopy methods to identify new bioactive small molecules and main group metal catalysis to prepare complex molecules through novel chemical reactions.