Job Opening

Computational Biologist — Population Genomics

Emeryville, CA


Octant is a well-backed team (Series A led by a16z) of experienced scientists and entrepreneurs at the frontiers of biology, chemistry, and computation. We are a small molecule therapeutics company scaling drug discovery to navigate the complexity of human diseases using an integrated platform combining synthetic biology, genomics, computation and high-throughput chemistry.

Octant is an equal opportunity company that deeply values diversity, equity, and inclusion, and welcomes applicants of all backgrounds. We’re committed to growing the company with a diversity of talented individuals and our team is dedicated to fostering an inclusive and supportive work environment for everyone.

Job Description

We are looking for computational and data scientists excited to work at the interfaces of functional genomics, statistical and population genetics, genomics, cell engineering, and data science. As a member of the Octant team, you’ll contribute to Octant’s scientific strategy by designing, executing on, and interpreting results for significant drug discovery programs. You’ll draw from diverse areas of biology to solve challenging problems beyond your area of expertise. In addition, you thrive on getting things done, are eager to trouble-shoot random tasks that arise in startups, and can navigate the uncertainty of an ever-changing and fast-paced environment.

In particular, we are looking for scientists who would be passionate about working on projects that involve using techniques such as deep mutational scanning to interpret large scale population genomic datasets such as UK BioBank.

  • Population Genomics – Work with large exome datasets and paired phenotype datasets (e.g., UK BioBank), and other large databases including TOPMED, TCGA, and ENCODE.

  • Functional Genomics – Statistical methodologies, computational pipelines, and custom analyses for interpreting functional genomic assays such as deep mutational scanning and MPRAs.

This job might be great for you if:
  • Have a PhD or equivalent experience in fields related to computational biology, bioinformatics, genetics. We are open to hiring at different experience levels.

  • Have programming experience in Python or R.

  • Have practical experience deriving insights from raw data and summary statistics of population-scale GWAS and/or genomic sequencing data.

  • Have a demonstrated record of working on and leading impactful projects.

  • Thrive in a fast-paced, collaborative, team-oriented startup environment.

For more information, please send a resume/CV and cover letter to and include "Population Genomics” and your name in the email’s subject line.

In your email, please also share a paper/preprint/software repo that best highlights your strengths so we can better understand the work you've led. If there is nothing public, please summarize that work in a few paragraphs. We'd love to also hear about things you've been proud to build or lead outside of science.

Medical, dental, & vision coverage with competitive compensation based on experience level.