Eric has been at Octant since 2018 and has spent the majority of his tenure building correctors for rare genetic diseases. He currently leads Octant's Fabry Disease program. Previously, he led the RHO-adRP program through early discovery. Eric is a molecular biologist by training with a background in synthetic biology and functional genomics. He completed his Ph.D. in Molecular Biology at UCLA in the lab of Sriram Kosuri.
His graduate work focused on constructing a massively parallel reporter assay for mapping olfactory receptor-odorant interactions and performing a deep mutational scan of the Beta-2 Adrenergic Receptor.
Outside of the lab you can find him playing tennis, sailing, or going to shows.
Papers
J. S. Bloom, L. Sathe, C. Munugala, E. M. Jones, M. Gasperini, N. B. Lubock, F. Yarza, E. M. Thompson, K. M. Kovary, J. Park, D. Marquette, S. Kay, M. Lucas, T. Love, A. Sina Booeshaghi, O. F. Brandenberg, L. Guo, J. Boocock, M. Hochman, S. W. Simpkins, I. Lin, N. LaPierre, D. Hong, Y. Zhang, G. Oland, B. J. Choe, S. Chandrasekaran, E. E. Hilt, M. J. Butte, R. Damoiseaux, C. Kravit, A. R. Cooper, Y. Yin, L. Pachter, O. B. Garner, J. Flint, E. Eskin, C. Luo, S. Kosuri, L. Kruglyak, V. A. Arboleda, Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples. Nat Biomed Eng. 5, 657–665 (2021).
E. M. Jones*, R. Jajoo*, D. Cancilla, N. B. Lubock, J. Wang, M. Satyadi, R. Cheung, C. de March, J. S. Bloom, H. Matsunami, S. Kosuri, A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing. Cell Syst. 8, 254-260.e6 (2019).
Jones EM*, Lubock NB*, Venkatakrishnan AJ, Wang J, Tseng AM, Paggi JM, Latorraca NR, Cancilla D, Satyadi M, Davis JE, Babu MM, Dror RO, Kosuri S. 2020. Structural and functional characterization of G protein–coupled receptors with deep mutational scanning. Elife 9:e54895.
Joshua S. Bloom, Eric M. Jones, Molly Gasperini, Nathan B. Lubock, Laila Sathe, Chetan Munugala, A. Sina Booeshaghi, et al. 2020. “Swab-Seq: A High-Throughput Platform for Massively Scaled up SARS-CoV-2 Testing.” medRxiv.
Jessica E. Davis, Kimberly D. Insigne, Eric M. Jones, Quinn A. Hastings, W. Clifford Boldridge, and Sriram Kosuri. 2020. “Dissection of c-AMP Response Element Architecture by Using Genomic and Episomal Massively Parallel Reporter Assays.” Cell Systems 11 (1): 75–85.
R. Cheung, K. D. Insigne, D. Yao, C. P. Burghard, J. Wang, Y.-H. E. Hsiao, E. M. Jones, D. B. Goodman, X. Xiao, S. Kosuri, A Multiplexed Assay for Exon Recognition Reveals that an Unappreciated Fraction of Rare Genetic Variants Cause Large-Effect Splicing Disruptions. Mol. Cell. 73, 183-194.e8 (2019).
Structure-based design of functional amyloid materials. Li D, Jones EM, Sawaya MR, Furukawa H, Luo F, Ivanova M, Sievers SA, Wang W, Yaghi OM, Liu C, Eisenberg DS. J Am Chem Soc. 2014 Dec 31;136(52):18044-51. doi: 10.1021/ja509648u. Epub 2014 Dec 19.
Howard, C. J., Abell, N. S., Osuna, B. A., Jones, E. M., Chan, L. Y., Chan, H., Artis, D. R., Asfaha, J. B., Bloom, J. S., Cooper, A. R., Liao, A., Mahdavi, E., Mohammed, N., Su, L. A., Uribe, G. A., & Kosuri, S. (2025). High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery. eLife, 13, Article RP104725.
