Lauren Orr
Lauren is an analytical scientist/chemical biologist who is excited about using HT mass spectrometry for drug discovery. She has experience in bottom-up proteomics, intact protein MS, and MS-based HTS.
Prior to Octant, Lauren received her PhD in Chemistry at UC Berkeley in Dan Nomura’s lab, where she used chemoproteomics platforms to discover covalent degrader compounds against undruggable targets. Also in the Nomura lab, she built a data analysis pipeline for intact protein HTS, and she deployed a new class ofphotoaffinity labeling probes for target ID in live cells. For her undergraduate studies, she attended Purdue University and earned BS’ in Chemistry and Pharmaceutical Science, with a minor in Biology.
Outside of work, Lauren loves running around the bay area, biking, reading, seeing live music, and competing in silly endurance challenges.
Papers
Orr LM, Tomlinson SJ, Grupe HR, Lim M, Ho E, Yilmaz H, Zhou G, Leon B, Olzmann JA, Nomura DK. DCAF16-Based Covalent Degradative Handles for Modular Design of Degraders. ACS Central Science, 2025,https://doi.org/10.1021/acscentsci.5c00959
Page ACS*, Orr LM*, Meyers ML, Belcher BP, Coffey TG, Scholz SO, Cismoski S, Nomura DK, Toste FD. Development of Second-Generation Acyl Silane Photoaffinity Probes for Live Cell Chemoproteomic Profiling. BioRxiv,2025, 655972. *Denotes co-first authorship
Lim M*, Do Cong T*, Orr LM, Toriki ES, Kile AC, Papatzimas JW, Lee E, Lin Y, Nomura DK. DCAF16-based Covalent Handle for the Rational Design of Molecular Glue Degraders. ACS Central Science, 2024, 10,1318-1331. PMID 39071058.